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    • Beneficiaries
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    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
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K. Box
Pion Inc. (UK) Ltd.

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Position

Chief Scientific Officer

Background

Karl Box was appointed as the Chief Scientific Officer at Sirius Analytical Ltd., in January 2015, where he has the overall responsibility for all scientific and chemistry related functions within the company. His expertise is in the field of physicochemical measurements where he has forged a successful career in the development of new instrumentation and assays for physicochemical property determination.

He has published on many topics including solubility and lipophilicity and its relationship to the Biopharmaceutical Classification System and explored the ideas of improving a compounds classification through the use of supersaturation and solubility enhancement strategies, all high-agenda items for the oral biopharmaceutics and drug delivery sectors.

Karl has been responsible for leading a team that has developed small-scale dissolution equipment with quantitation by in-situ UV-fibre optic spectroscopy and introduced in-situ physiological pH gradients as a research tool for understanding API behavior following gastric to intestinal pH transitions. As well as providing information on dissolution performance these dynamic techniques provide additional understanding on supersaturation and intestinal precipitation behavior of APIs. The introduction of biphasic dissolution assays with lipid layer has also provided a tool for understanding and modeling the oral absorption outcome of orally taken drugs. He is involved in the OrBiTo project, a large consortium of pharma and academia, which aims to develop Oral Biopharmaceutics Tools for bringing small molecule drugs more quickly through company pipelines. 

Karl has a broad knowledge of the pharmaceutical industry from discovery topics through to development strategies. He is an established speaker at many international scientific meetings and conferences and recently contributed to the AAPS eLearning webinar series. He has over 30 peer reviewed publications in scientific journals.

Role in PEARRL

Main Supervisor ESR 10, Co-Supervisor ESR 6

Key Publications

  • Box, K. J., Comer, J E A., Current Drug Metabolism, 2008, 9 (9), 869-878; Using measured pKa, LogP and solubility to investigate supersaturation and predict BCS class.
  • Box, K. J., Comer, J. E. Gravestock, T. Stuart, M., Chemistry and Biodiversity, 2009, 6, 1767-1788; New ideas about the solubility of drugs.
  • Hsieh, Y. L., Ilevbare, G. A., Van Eerdenbrugh, B., Box, K. J., Sanchez-Felix, M. V., Taylor, L. S. Pharm. Res. 2012, 29 (10), 2738-2753; pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties.
  • Lennernas, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J.; Lindahl, A., McAllister, M., Muenster, U., Mullertz, A., Ojala, K., Pepin, X., Reppas, C., Rostami-Hodjegan, A., Verwei, M., Weitschies, W., Wilson, C., Karlsson, C., Abrahamsson, B. Eur J Pharm Sci 2013; Oral biopharmaceutics tools - Time for a new initiative - An introduction to the IMI project OrBiTo.
  • Bergstrom, C. A., Holm, R., Jorgensen, S. A., Andersson, S. B., Artursson, P., Beato, S., Borde, A., Box, K., Brewster, M., Dressman, J., Feng, K. I., Halbert, G., Kostewicz, E., McAllistar, M., Muenster, U., Thinnes, J., Taylor, R., Mullertz, A., Eur J Pharm Sci 2013; Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs.
  • Anura S. Indulkar, Karl J. Box, Robert Taylor, Rebeca Ruiz, Lynne S. Taylor., Mol. Pharmaceutics, 2015, 12 (7), 2365–2377; pH-Dependent Liquid–Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs.
  • Box, K. J., Comer, J., Taylor, R., Karki, S., Ruiz, R., Price, R. and Fotaki, N., AAPS Pharm. Sci. Tech., 2015; Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration.
  • Fotaki, N. Grignard, E. McAllister, M. Taylor, R. Box, K., Eur J Pharm Sci 2016; Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies.
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This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
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