Dr. N. Fotaki
University of Bath, School of Pharmacy, UK

Position
Senior Lecturer (Associate Professor) in Pharmaceutics at the Department of Pharmacy and Pharmacology at University of Bath, UK

Background
Dr Nikoletta Fotaki is a UK registered Greek Pharmacist, with an MSc in Toxicology and a PhD in Biopharmaceutics-Pharmacokinetics. She participated in several research projects in the School of Pharmacy of the National and Kapodistrian University of Athens and in Hoffman La Roche (Pharmaceutical and Analytical R&D, New Jersey, USA) before her academic appointment at the University of Bath. She has also worked in the National Organisation for Medicines in Greece. She is a reviewer and scientific advisor of several scientific journals, an Associate Editor for AAPS Open and member of the editorial board of Dissolution Technologies and DiePharmazie. She is an Associate Fellow of the Higher Education Academy and has been involved in the evaluation of several research proposals. She is also an Adjunct Assistant Professor in the University of Waterloo (Canada). She is the chair of the IVRDT Focus Group of AAPS.

Dr Fotaki’s expertise and research are focused on PBPK modeling, drug absorption, development of in vitro screening tools and associated software for predicting absorption and in vivo performance in normal populations and in special populations (i.e. paediatrics, disease states), biorelevant dissolution methods, dissolution imaging, development of in vitro-in vivo correlations and relations, formulation development, animal models for the prediction of absorption, methods for reduction/ refinement/ replacement of animal experimentation, biowaivers, dissolution testing, design of BA/BE studies, in silico models, pharmacokinetics.

Role in PEARRL
Main Supervisor ESR 12 and ESR 15, Co-Supervisor ESR 8, ESR 11 and ESR 13

Key Publications
  • Mercuri A., Fares R., Bresciani M., Fotaki N. (2016) An in vitro–in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics. Int J Pharm, 499, 330-342.
  • Maharaj A.R., Edginton A.N., Fotaki N. (2016) Assessment of Age-Related Changes in Pediatric Gastrointestinal Solubility, Pharm Res, 33(1), 52-71.
  • Box K., Comer J., Taylor R., Karki S., Ruiz R., Price R., Fotaki N. (2015) Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration. AAPS PharmSciTech (Special Issue; Theme: Recent Advances In Dissolution And In Vitro Release Of Dosage Forms) DOI: 10.1208/s12249-015-0362-5
  • Maharaj A.R., Fotaki N., Edginton A. (2015) Parameterization of Small Intestinal Water Volume using PBPK Modelling. Eur J Pharm Sci., 67, 55-64.
  • Fagiolino P., Vázquez M., Ibarra M., Magallanes L., Guevara N., Fotaki N. (2014) Sex- and smoke-related differences in gastrointestinal transit of cyclosporin A microemulsion capsules. Eur J Pharm Sci., 63, 140-146.
  • Batchelor H. K., Fotaki N., Klein S. (2014). Paediatric oral biopharmaceutics: key considerations and current challenges, Adv Drug Deliv Rev., 73, 102-126.
  • Fotaki N., Klein S. (2013). Mechanistic understanding of the effect of PPIs and acidic carbonated beverages on the oral absorption of itraconazole based on absorption-modeling with appropriate in-vitro data. Mol Pharm, 10 (11), 4016–4023
  • Tomaszewska I., Karki S., Shur J., Price R. and Fotaki N. (2013). Pharmaceutical characterisation and evaluation of cocrystals: Importance of in vitro dissolution conditions and type of coformer. Int J Pharm, 453 (2), 380-8.