ESR 1: Niklas Köhl
Lipid based formulations (LBF) as Bio-enabling formulation technology 

PEARRL research
Niklas will develop novel lipid-based formulations (LBF) to overcome solubility limited oral absorption and establish an industrial score-card to guide LBF design. Further, he will work on in silico models for predicting in vivo performance of LBF by applying a recent published model established in the Kuentz lab. Moreover, Niklas will validate the utility of in silico modelling to predict in vivo performance using three prototype bio-enabling formulations.

Host
University College Cork  (UCC), School of Pharmacy

Supervisory Team
Dr. B. Griffin (UCC), Prof. M. Kuentz (FHNW), Dr. R. Holm (Janssen)

Scientific Background
Niklas studied pharmacy at the Johann Wolfgang von Goethe University in Frankfurt am Main, Germany, from 2011 to 2015. During an internship after his studies he extended his knowledge about formulation development and screening as well as primary packaging development at Hoffmann-La Roche AG in Basel, Switzerland.
Peer Reviewed Journal Articles
  • Price, D. J., Ditzinger, F., Koehl, N. J., Jankovic, S., Tsakiridou, G., Nair, A., Holm, R., Kuentz, M., Dressman, J.B., Saal, C. (2018). Approaches to Increase Mechanistic Understanding and Aid in the Selection of Precipitation Inhibitors for Supersating Formulations - A PEARRL Review. Journal of Pharmacy and Pharacology. doi.org/10.1111/jphp.12927
  • Jankovic, S., Tsakiridou, G., Ditzinger, F., Koehl, N.J., Price, D.J., Ilie, A.R., Kalantzi, L., Kimpe, K., Holm, R., Nair, A., Griffin, B., Saal, C., Kuentz, M. (2018). Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - A PEARRL Review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12948
  • Henze, L.J., Koehl, N.J., O'Shea, J.P., Kostewicz, E.S., Holm, R., Griffin, B.T. (2018). The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12912
  • Ditzinger, F., Price, D.J., Ilie, A.R., Köhl, N.J., Jankovic, S., Tsakiridou, G., Aleandri, S., Kalantzi, L., Holm, R., Nair, A., Saal, C., Brendan Griffin, B., Kuentz, M. (2018). Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review. Journal of Pharmacy and Pharmacology. doi: 10.1111/jphp.12984
Contact
niklas.koehl [at] ucc [dot] ie