ESR 10: Patrick O'Dwyer
Small-scale dissolution assays for evaluating API and formulation behaviour

PEARRL research

Patrick will develop novel, small-scale in vitro dissolution assays that mimic transitions from gastric pH to intestinal pH environments. Furthermore, he will optimise the use of biorelevant media and biphasic dissolution assays for model-ling compound solubilisation and oral absorption and understand supersaturation effects and precipitation risk of different drug substance and dosage forms.

Host

Pion Inc. (UK) Ltd., R&D

Supervisory Team

K. Box (Pion), Prof. C. Reppas (UoA), Dr. E Kostewicz (JWGU)

Scientific Background

Patrick studied pharmacy at the University College Cork, Ireland, from 2011 to 2015, where he won several awards – among them the “School of Pharmacy Medal for highest achieving student in the BPharm degree in 2015”.
He then completed the National Pharmacy Internship Programme with the Royal College of Surgeons in Ireland (RCSI) from 2015 to 2016. Moreover, he gained valuable experience as a quality assurance specialist at Gilead Sciences Ireland UC and as a pre-registration pharmacist at Walsh’s Pharmacy.

Peer Reviewed Journal Articles

O’Dwyer PJ, Litou C, Box KJ, Dressman JB, Kostewicz ES, Kuentz M, Reppas C. In vitro methods to assess drug precipitation in the fasted small intestine - a PEARRL review. J Pharm Pharmacol [epub ahead of print]. 2018; Available from: http://doi.wiley.com/10.1111/jphp.12951.

Conference Publications

• O’Dwyer PJ, Box KJ, Reppas C. Small Scale Biphasic Dissolution Testing of Itraconazole (ITZ) Formulations with a pH Shift. UKICRS Annual Meeting 2018.
• Watson H, Box KJ, O'Dwyer PJ, Gehris A. Understanding Drug Release Mechanisms of Metformin using complementary in vitro Dissolution Tools. AAPS Annual Meeting 2017.
• O’Dwyer PJ, Box KJ, Watson H, Taylor R. In Vitro Modelling of Propranolol Immediate Release (IR) and Extended Release (ER) Formulations using a Three Chamber Dissolution Apparatus. AAPS Annual Meeting 2017.
• O’Dwyer PJ, Comer J, Taylor R, Box KJ. Small Scale Biphasic Dissolution testing of Dipyridamole Suspension. IAPC-6 Meeting 2017.

Contact

PODwyer [at] pion-inc [dot] com