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ESR 12: Mariana Guimarães
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PEARRL research
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Mariana will develop a biorelevant dissolution methodology for paediatric populations. In addition, she will develop paediatric absorption model, integrated into a PBPK model, which adjusts for physiological differences as a function of age. Based on comparison with in vivo data, she will further evaluate the in vitro and in silico models.
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Host
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University of Bath, School of Pharmacy
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Supervisory Team
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Scientific Background
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Mariana completed her Master of Science in pharmaceutical sciences at the Faculty of Pharmacy of the University of Porto, Portugal. She did an Erasmus internship program at the University of Strathclyde in Glasgow, Scotland. During that time, Mariana developed a research project concerning the microfluidic manufacturing of phospholipid nanoparticles and performed stability studies, as well as evaluation of encapsulation efficiency and drug release.
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Peer Reviewed Journal Articles
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Guimarães, M., Statelova, M., Holm, R., Reppas, C., Symilllides, M., Vertzoni, M., Fotaki, N. (2018). Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12955
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Contact
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mgsc20 [at] bath [dot] ac [dot] uk
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