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    • Beneficiaries
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    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
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ESR 12: Mariana Guimarães
Developing in vitro and in silico approaches to predict clinical outcomes: focus on paediatrics

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PEARRL research

Mariana will develop a biorelevant dissolution methodology for paediatric populations. In addition, she will develop paediatric absorption model, integrated into a PBPK model, which adjusts for physiological differences as a function of age. Based on comparison with in vivo data, she will further evaluate the in vitro and in silico models.

Host

University of Bath, School of Pharmacy

Supervisory Team

Dr. Fotaki (UBAH), Dr. M. Vertzoni (UoA), Dr. P. Ghiotti (UCB)

Scientific Background

Mariana completed her Master of Science in pharmaceutical sciences at the Faculty of Pharmacy of the University of Porto, Portugal. She did an Erasmus internship program at the University of Strathclyde in Glasgow, Scotland. During that time, Mariana developed a research project concerning the microfluidic manufacturing of phospholipid nanoparticles and performed stability studies, as well as evaluation of encapsulation efficiency and drug release.
Peer Reviewed Journal Articles
Guimarães, M., Statelova, M., Holm, R., Reppas, C., Symilllides, M., Vertzoni, M., Fotaki, N. (2018).  Biopharmaceutical considerations in paediatrics with a view to the evaluation of orally administered drug products – a PEARRL review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12955
Contact
mgsc20 [at] bath [dot] ac [dot] uk
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This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
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