ESR 14: Alexandra-Roxana Ilie
Developing in vitro and in silico models to predict in vivo performance of supersaturated self-nano-emulsifying drug delivery systems (SNEDDS)

PEARRL research
Alexandra-Roxana will establish a biopharmaceutics tool to investigate the in vivo performance of supersaturated SNEDDS, use the in vitro understanding to develop an in silico model to predict the in vivo performance and compare the in vitro and in silico predictions to observations in vivo.

Host
Janssen Pharmaceutical N.V.

Supervisory Team
Dr. R. Holm (Janssen), Dr. B. Griffin (UCC), Dr. M. Vertzoni (UoA)

Scientific Background
I studied Pharmacy (BSc, MSc) at the “Carol Davila” University of Medicine and Pharmacy in Bucharest, Romania (2008-2013). During these five years, I had different internships in community and hospital pharmacies, but also in the Production Department for Parenterals in a pharmaceutical company. After finishing my studies in Romania, I followed the “Drug Innovation” research-oriented Master programme (2014-2016) at Utrecht University, the Netherlands, where I worked on research projects for characterization of liposomes encapsulating glucocorticosteroids and of viral vaccines products. I gained experience in analytical method development while working at Janssen Vaccines and Prevention in Leiden, the Netherlands for 8 months. My research interests are focused on drug delivery systems for enhanced bioavailability, targeted delivery to pathological site and limitation of side effects.
Peer Reviewed Journal Articles
  • Ditzinger, F., Price, D.J., Ilie, A.R., Köhl, N.J., Jankovic, S., Tsakiridou, G., Aleandri, S., Kalantzi, L., Holm, R., Nair, A., Saal, C., Brendan Griffin, B., Kuentz, M. (2018). Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review. Journal of Pharmacy and Pharmacology. doi: 10.1111/jphp.12984
  • Jankovic, S., Tsakiridou, G., Ditzinger, F., Koehl, N.J., Price, D.J., Ilie, a.R., Kalantzi, L., Kimpe, K., Holm, R., Nair, A., Griffin, B., Saal, C., Kuentz, M. (2018). Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - A PEARRL Review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12948
Contact
ailie [at] its [dot] jnj [dot] com