PEARRL
  • PEARRL Project
    • Beneficiaries
    • Partner Organisation
    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
  • PEARRL Project
    • Beneficiaries
    • Partner Organisation
    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
Picture

ESR 3: Daniel Price
Development of Novel Mesoporous Silica-based formulations

Picture

PEARRL research

Daniel will aim to develop a deeper understanding of mesoporous silica formulations by investigating four key areas: (1) Uptake of API into the silica, (2) interaction of API with the pores, (3) release of API from the pores and (4) interactions with precipitation inhibitors. This newfound fundamental understanding will be used to develop an industrial score-card to aid in the decision making process surrounding the selection of mesoporous silica as an appropriate bio-enabling formulation in drug development.
Daniel’s research perfectly fits in the context of a recently escalating interest in mesoporous silica formulations for the oral delivery of poorly soluble active pharmaceutical ingredients. In spite of a large number of recent publications demonstrating the utility and efficiency of mesoporous silica, there are key gaps in the fundamental understanding of this technology and the underlying principles that govern its efficiency and ultimate success.

Host

Merck Group, Molecule Characterisation

Supervisory Team

Dr. C. Saal (Merck), Dr. A. Nair (Merck), Prof. J. Dressman (JWGU), Prof M. Kuentz (FHNW)

Scientific Background

Daniel received his Bachelor of Science and his Master of Chemistry in Industrial Medicinal Chemistry from the University of Leeds (2012-2016). His master’s thesis was entitled “The Controlled Delivery of Doxorubicin from Novel Biodegradable Polymer Nanoparticles”,  which was awarded the prize for the Top Master’s Research Project (University of Leeds, 2016). Moreover, he reveived the Craig Jordan Prize for Medicinal Chemistry (University of Leeds, 2016) and the Salters’ Graduate Prize (The Salters’ Company, 2016).
Daniel has also already gained industrial experience at Pfizer (2014-2015), where he worked on a project surrounding the “Solubility Enhancement of Orally Delivered Drugs with Mesoporous Silica”.
In December 2016, Daniel was awarded the The Salters’ Graduate Award, a national UK prize awarded to 5 chemistry graduates nationwide, for achievement in their MChem degrees (read more).
Peer Reviewed Journal Articles
  • Price, D. J., Ditzinger, F., Koehl, N. J., Jankovic, S., Tsakiridou, G., Nair, A., Holm, R., Kuentz, M., Dressman, J.B., Saal, C. (2018). Approaches to Increase Mechanistic Understanding and Aid in the Selection of Precipitation Inhibitors for Supersating Formulations - A PEARRL Review. Journal of Pharmacy and Pharacology. doi.org/10.1111/jphp.12927
  • Jankovic, S., Tsakiridou, G., Ditzinger, F., Koehl, N.J., Price, D.J., Ilie, a.R., Kalantzi, L., Kimpe, K., Holm, R., Nair, A., Griffin, B., Saal, C., Kuentz, M. (2018). Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - A PEARRL Review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12948
  • Ditzinger, F., Price, D.J., Iliee, A.R., Köhl, N.J., Jankovic, S., Tsakiridou, G., Aleandri, S., Kalantzi, L., Holm, R., Nair, A., Saal, C., Brendan Griffin, B., Kuentz, M. (2018). Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review. Journal of Pharmacy and Pharmacology. doi: 10.1111/jphp.12984
Contact
daniel-joseph.price [at] merckgroup [dot] com
Picture
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
Disclaimer | Member Area
© accelopment Schweiz AG 2019. ALL RIGHTS RESERVED.