ESR 2: Felix Ditzinger
Supersaturating oral delivery systems of poorly water-soluble compounds produced by hot melt extrusion

PEARRL research
Felix will develop novel types of supersaturating drug delivery systems. A focus is on amorphous solid dispersions in special polymeric hybrid matrices that are prepared by hot melt extrusion. The specific molecular interactions with poorly soluble drugs are studied and promising bio- enabling formulations are selected for additional characterization in vitro and potentially also for in vivo studies.

Host
University of Applied Sciences & Arts Northwestern Switzerland, Institute of Pharma Technology

Supervisory Team
Prof. M. Kuentz (FHNW), Dr. B. Griffin (UCC), Dr. R. Holm (Janssen)

Scientific Background
Felix Ditzinger became interested in science during an internship at the Sanford-Burnham Medical Research Institute in San Diego, USA. He then studied pharmacy at the Johann Wolfgang von Goethe University in Frankfurt am Main, Germany, from 2011 to 2016.
Felix finished his first and second state exam in pharmaceutical sciences in 2013 and 2015, respectively. His third will be completed in 2016. During an internship at Sanofi Aventis in 2016, Felix developed different analytical methods for new compounds by using HPLC technology.
Peer Reviewed Journal Articles
  • Price, D. J., Ditzinger, F., Koehl, N. J., Jankovic, S., Tsakiridou, G., Nair, A., Holm, R., Kuentz, M., Dressman, J.B., Saal, C. (2018). Approaches to Increase Mechanistic Understanding and Aid in the Selection of Precipitation Inhibitors for Supersating Formulations - A PEARRL Review. Journal of Pharmacy and Pharacology. doi.org/10.1111/jphp.12927
  • Jankovic, S., Tsakiridou, G., Ditzinger, F., Koehl, N.J., Price, D.J., Ilie, a.R., Kalantzi, L., Kimpe, K., Holm, R., Nair, A., Griffin, B., Saal, C., Kuentz, M. (2018). Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - A PEARRL Review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12948
  • Ditzinger, F., Price, D.J., Iliee, A.R., Köhl, N.J., Jankovic, S., Tsakiridou, G., Aleandri, S., Kalantzi, L., Holm, R., Nair, A., Saal, C., Brendan Griffin, B., Kuentz, M. (2018). Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review. Journal of Pharmacy and Pharmacology. doi: 10.1111/jphp.12984
Poster presentation
  • 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in  Granada, Spain
  • AAPS Annual meeting an Exposition 2018
Contact
felix.ditzinger [at] fhnw [dot] ch