Prof. C. Reppas
National and Kapodistrian University of Athens, Department of Pharmacy, Greece

Position

Professor of Pharmaceutics, Department of Pharmacy

Background

Professor Reppas received his B. Pharm degree in Pharmacy from the N&K University in Athens in 1982 and his Ph.D in 1986 from the same University. From 1988 to 1989 he completed a postdoctoral fellowship in Pharmaceutics at the University of Michigan (USA) and then he joined the N&K University of Athens in 1989 as a Lecturer. He has held research positions with the University of London (UK), the University of Michigan (USA), Glaxo R&D (UK) and the University of Frankfurt (Germany).

Professor Reppas’ research interests focus to the effects of gastrointestinal physiology on intraluminal performance of xenobiotics and the development of in vitro tests that are predictive of the intraluminal dosage form and drug performance. He is coauthor of more than 100 peer reviewed papers in international journals, two books and one patent.

Role in PEARRL

Main Supervisor ESR 7, Co-Supervisor ESR 4 and ESR 10

Key Publications

• Diakidou A, Vertzoni M, Dressman J, Reppas C. Estimation of intragastric drug solubility in the fed state: Comparison of various media with data in aspirates. Biopharm Drug Dispos 30:318-325 (2009)
  
• Psachoulias D, Vertzoni M, Goumas L, Kalioras V, Beato S, Butler J, Reppas C. Precipitation in and supersaturation of contents of the upper small intestine after administration of two weak bases to fasted adults. Pharm Res 28: 3145-3158 (2011)
• Hens B, Brouwers J, Anneveld B, Corsetti M, Symillides M, Vertzoni M, Reppas C, Turner DB, Augustijns P. Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools. Eur J Pharm Sci 63:233-42 (2014)
• Dimopoulou M, Mourouti CS, Vertzoni M, Symillides M, Reppas C. In-vitro evaluation of performance of solid immediate release dosage forms of weak bases in upper gastrointestinal lumen: experience with miconazole and clopidogrel salts. J Pharm Pharmacol in press
• Markopoulos C, Andreas CJ, Vertzoni M, Dressman J, Reppas C. In-vitro simulation of luminal conditions for evaluation of performance of oral drug products: Choosing the appropriate test media. Eur J Pharm Biopharm 93:173-82 (2015)
• Kourentas A, Vertzoni M, Stavrinoudakis N, Symillidis A, Brouwers J, Augustijns P, Reppas C, Symillides M. An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation. Eur J Pharm Sci 82:106-14 (2016)