Peer Reviewed Journal Articles

ESR 9: Laura Henze
Exploring the utility of the porcine model for predicting bio-enabling oral drug products performance in humans

PEARRL research
Laura will develop biorelevant in vitro models for the pig that improve interpretation of preclinical results and comparatively evaluate the suitability of the ‘pig’ model for predicting formulation behaviour in humans and will develop improved PBPK in silico ‘porcine’ models that take account of species-specific factors.

Host
University College Cork  (UCC), School of Pharmacy

Supervisory Team
Dr. B. Griffin (UCC), Dr. M. Vertzoni (UoA), Dr. R. Holm (Janssen)

Scientific Background
Laura studied pharmacy at the Goethe University of Frankfurt, Germany (2011-2015). She then completed internships at Corden Pharma, Plankstadt, Germany, where she worked in the area of quality control and analytical development. Moreover, Laura gained experience as an intern at Merck Group (also beneficiary in PEARRL), focusing on risk and inspection management in the context of quality assurance.
Peer Reviewed Journal Articles
  • Henze, L. J., Griffin, B. T., Christiansen, M., Bundgaard, C., Langguth, P., & Holm, R. (2018). Exploring gastric emptying rate in minipigs: Effect of food type and pre-dosing of metoclopramide. European Journal of Pharmaceutical Sciences, 118, 183-190. doi.org/10.1016/j.ejps.2018.03.017
  • Henze, L.J., Koehl, N.J., O'Shea, J.P., Kostewicz, E.S., Holm, R., Griffin, B.T. (2018). The pig as a pre-clinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review. Journal of Pharmacy and Pharmacology. doi.org/10.1111/jphp.12912
Contact
laura.henze [at] ucc [dot] ie