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  • PEARRL Project
    • Beneficiaries
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    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
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Dr. E. Kostewicz
Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology, Germany

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Position

Senior Scientist in the Institute of Pharmaceutical Technology at the Johan Wolfgang Goethe University in Frankfurt am Main

Background

Edmund Kostewicz received a BSc. from the University of Adelaide (Australia). His Honours Degree was awarded at Flinders University (Australia) and his PhD from the University of South Australia (Australia) under the supervision of Prof. Lloyd Sansom.
Following completion of his PhD, he held a Post Doc position in the Institute for Pharmaceutical Technology at the Goethe University (Germany). He then took up a position as Research Scientist within the Department of Biopharmaceutics at AstraZeneca (Sweden) and then as Project Coordinator within the Centre for Drug Candidate Optimisation at Monash University (Australia). Edmund has held his current position in the Institute for Pharmaceutical Technology at Goethe University since 2009.
Research Interest:  Tools for predicting oral drug absorption in humans
•    In vitro and in vivo models for predicting oral drug absorption in humans
•    In vivo prediction of gastrointestinal (GI) precipitation using the transfer model

Role in PEARRL

Main Supervisor ESR 6, Co-Supervisor ESR 10

Key Publications

  • O'Shea JP, Faisal W, Ruane-O'Hora T, Devine KJ, Kostewicz ES, O'Driscoll CM, Griffin BT. Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments. Eur J Pharm Biopharm. 2015
  • Bergström CA, Holm R, Jørgensen SA, Andersson SB, Artursson P, Beato S, Borde A, Box K, Brewster M, Dressman J, Feng KI, Halbert G, Kostewicz E, McAllister M, Muenster U, Thinnes J, Taylor R, Mullertz A. (2014) Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs. Eur J Pharm Sci. Jun 16;57:173-99
  • Griffin BT, Kuentz M, Vertzoni M, Kostewicz ES, Fei Y, Faisal W, Stillhart C, O'Driscoll CM, Reppas C, Dressman JB. (2014) Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate. Eur J Pharm Biopharm. Apr;86(3):427-37.
  • Kostewicz, E. S., Aarons, L., Bergstrand, M., Bolger, M. B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami, A., Sjogren, E., Tannergren, C., Turner, D. B., Wagner, C., Weitschies, W., Dressman, J. (2014) PBPK models for the prediction of in vivo performance of oral dosage forms. Eur J Pharm Sci. Jun 16; 57:300-21.
  • Kostewicz, E. S., Abrahamsson, A., Brewster, M., Brouwers, J., Butler, J., Carlert, S., Dickinson, P. A., Dressman, J. B., Holm, R., Klein, S., Mann, J., McAllister, M., Minekus, M., Muenster, U., Müllertz, A., Verweij, M., Vertzoni, M., Weitschies, W., Augustijns, P.(2014) In vitro models for the prediction of in vivo performance of oral dosage forms. European Journal of Pharmaceutical Sciences. Eur J Pharm Sci. Jun 16;57:342-66.
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This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
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