Dr. E. Kostewicz
Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology, Germany

Position
Senior Scientist in the Institute of Pharmaceutical Technology at the Johan Wolfgang Goethe University in Frankfurt am Main

Background
Edmund Kostewicz received a BSc. from the University of Adelaide (Australia). His Honours Degree was awarded at Flinders University (Australia) and his PhD from the University of South Australia (Australia) under the supervision of Prof. Lloyd Sansom.
Following completion of his PhD, he held a Post Doc position in the Institute for Pharmaceutical Technology at the Goethe University (Germany). He then took up a position as Research Scientist within the Department of Biopharmaceutics at AstraZeneca (Sweden) and then as Project Coordinator within the Centre for Drug Candidate Optimisation at Monash University (Australia). Edmund has held his current position in the Institute for Pharmaceutical Technology at Goethe University since 2009.
Research Interest:  Tools for predicting oral drug absorption in humans
•    In vitro and in vivo models for predicting oral drug absorption in humans
•    In vivo prediction of gastrointestinal (GI) precipitation using the transfer model

Role in PEARRL
Main Supervisor ESR 6, Co-Supervisor ESR 10

Key Publications
  • O'Shea JP, Faisal W, Ruane-O'Hora T, Devine KJ, Kostewicz ES, O'Driscoll CM, Griffin BT. Lipidic dispersion to reduce food dependent oral bioavailability of fenofibrate: In vitro, in vivo and in silico assessments. Eur J Pharm Biopharm. 2015
  • Bergström CA, Holm R, Jørgensen SA, Andersson SB, Artursson P, Beato S, Borde A, Box K, Brewster M, Dressman J, Feng KI, Halbert G, Kostewicz E, McAllister M, Muenster U, Thinnes J, Taylor R, Mullertz A. (2014) Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs. Eur J Pharm Sci. Jun 16;57:173-99
  • Griffin BT, Kuentz M, Vertzoni M, Kostewicz ES, Fei Y, Faisal W, Stillhart C, O'Driscoll CM, Reppas C, Dressman JB. (2014) Comparison of in vitro tests at various levels of complexity for the prediction of in vivo performance of lipid-based formulations: case studies with fenofibrate. Eur J Pharm Biopharm. Apr;86(3):427-37.
  • Kostewicz, E. S., Aarons, L., Bergstrand, M., Bolger, M. B., Galetin, A., Hatley, O., Jamei, M., Lloyd, R., Pepin, X., Rostami, A., Sjogren, E., Tannergren, C., Turner, D. B., Wagner, C., Weitschies, W., Dressman, J. (2014) PBPK models for the prediction of in vivo performance of oral dosage forms. Eur J Pharm Sci. Jun 16; 57:300-21.
  • Kostewicz, E. S., Abrahamsson, A., Brewster, M., Brouwers, J., Butler, J., Carlert, S., Dickinson, P. A., Dressman, J. B., Holm, R., Klein, S., Mann, J., McAllister, M., Minekus, M., Muenster, U., Müllertz, A., Verweij, M., Vertzoni, M., Weitschies, W., Augustijns, P.(2014) In vitro models for the prediction of in vivo performance of oral dosage forms. European Journal of Pharmaceutical Sciences. Eur J Pharm Sci. Jun 16;57:342-66.