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    • Beneficiaries
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    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
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ESR 13: Ioannis Loisios-Konstantinidis
Extension of biowaivers to BCS class II compound using biorelevant dissolution testing

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PEARRL research

Ioannis will apply biorelavant dissolution testing to BCS class II compounds with a view of replacing in vivo pharmacokinetic studies with in vitro tests to determine bioequivalence in the fasted and fed state. The results will be utilized to fully characterize formulations containing BCS class II drugs and will be coupled with in silico models in order to create new in vitro methods for predicting in vivo performance and also establish a "safe space" between bio- and therapeutic- equivalence of bio-enabling formulations containing BCS class II compounds with the aim of validating the proposed methods.

Host

Johann Wolfgang Goethe University, Institute of Pharmaceutical Technology

Supervisory Team

Prof. J. Dressman (JWGU), Dr. N. Fotaki (UBAH), Dr. M. McAllister (Pfizer)

Scientific Background

Ioannis received his Diploma of Pharmacy from the School of Pharmacy, National and Kapodistrian University of Athens, Greece (2011-2016). During his Erasmus+ semester at the Department of Pharmacokinetics and Toxicokinetics, Aix-Marseille University, France, Ioannis completed his diploma thesis, which was entitled: "Pharmacokinetic Modeling & Simulation of Time-Lags observed in the Enterohepatic Recirculation using Differential Difference Equations: Numerical and Analytical Approaches."
Contact
Loisios-Konstantinidis [at] em [dot] uni-frankfurt [dot] de
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This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
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