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    • Beneficiaries
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    • People >
      • Supervisors >
        • Prof. B. Griffin
        • Prof. M. Kuentz
        • Dr. C. Saal
        • Dr. L. Kalantzi
        • Dr. E. Kostewicz
        • Prof. C. Reppas
        • Prof. J. Dressman
        • Dr. N. Fotaki
        • Dr. R. Holm
        • Dr. M. Vertzoni
        • Dr. K. Box
        • Prof. C. O'Driscoll
      • Researchers >
        • Niklas Köhl (ESR1)
        • Felix Ditzinger (ESR 2)
        • Daniel Price (ESR 3)
        • Georgia Tsakiridou (ESR 4)
        • Sandra Jankovic (ESR 5)
        • Chara Litou (ESR 6)
        • Christina Pentafragka (ESR 7)
        • Rafael Leal Monteiro Paraiso (ESR 8)
        • Laura Henze (ESR 9)
        • Patrick O'Dwyer (ESR 10)
        • Marina Statelova (ESR 11)
        • Mariana Guimarães (ESR 12)
        • Ioannis Loisios-Konstantinidis (ESR 13)
        • Alexandra-Roxana Ilie (ESR 14)
        • Angela Effinger (ESR 15)
      • Scientific Advisory Board >
        • Prof. Carla Caramella
        • Dr. Paul Dickinson
        • Dr. Andrea Edginton
        • Dr. Susanne Keitel
        • Dr. Mehul Mehta
    • PEARRL Wiki >
      • FAQ
      • Glossary
  • Research
    • Workplan
    • WP1: Bio-enabling formulations
    • WP2: Biopharmaceutical tools
    • WP3: In silico methods
    • Results >
      • Scientific Publications
      • Conference Contributions
      • InfoPEARRLs
      • Media
  • Training
    • Local
    • Network-wide
    • PEARRL Online Learning Portal
    • Member Area
  • News
  • Events & Meetings
    • Webinar: Regulatory Science Apprentice
    • Annual Meeting 2019
    • Model Informed Drug Development Symposium 2019
    • Annual Meeting 2018
    • Regulatory Science Symposium 2018
    • Annual Meeting 2017
    • Regulatory Science Symposium 2017
    • PEARRL Calendar
    • International Conferences
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ESR 15: Angela Effinger
Developing in vitro and in silico approaches to predict the impact of Gastrointestinal Disease states on drug product performance

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PEARRL research

Angela will develop clinical relevant dissolution methodology for patients with gastrointestinal diseases. In addition, she will develop an absorption model for gastrointestinal diseases that takes into account differing physiological conditions. Based on comparison with in vivo data, she will further evaluate the in vitro and in silico models.

Host

University of Bath, Department of Pharmacy and Pharmacology

Supervisory Team

Dr. N. Fotaki (UBAH), Prof. C. O’Driscoll (UCC), Dr. M. McAllister (Pfizer)

Scientific Background

Angela studied pharmacy at the Albert-Ludwigs-University of Freiburg, Germany. After her basic studies she did an Erasmus Placement internship in the department of pharmaceutical technology at the University of Montpellier 1, France, where she worked with polyionic-complex micelles for the delivery of siRNA. During an internship in the department of Formulation Research & Development at Hoffmann-La Roche AG, Basel, Switzerland, she worked on a pediatric oral suspension formulation and gained insight into the formulation development of small molecules.
Peer Reviewed Journal Articles
  • Chara Litou C., Effinger A., Kostewicz E.S., Box K.J., Fotaki N., Dressman J.B. (2018). Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/jphp.12983
  • Effinger, A., O'Driscoll, C. M. O. D., McAllister, M., & Fotaki, N. (2018). Impact of Gastrointestinal Disease States on Oral Drug Absorption – implications for formulation design – a PEARRL review. Journal of Pharmacy and Pharmacology. DOI: 10.1111/jphp.12928
Contact
a.effinger [at] bath [dot] ac [dot] uk
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This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 674909.
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