Industrial commentary by Dr. Rene Holm on bridging the gaps between academic research and industrial drug product developments in Advanced drug delivery reviews
PEARRL's Dr. Rene Holm (Jannsen) recently published a review in Advanced Drug Delivery Reviews highlighting the importance of joint academia-industry research consortia, such as PEARRL, for advancing innovation in the pharmaceutical drug development field. Dr. Holm gives examples of where academia and industry have successfully collaborated withing large multi-partner networks to produce major advances in scientific understanding and novel drug delivery technologies. He also highlights the importance that all stakeholders in the the Pharmaceutical ecosystem (figure insert), including academia, industry, CRO's, service/technology providers, etc., are involved in such consortia, so that new technological advances meets the needs of the various stakeholders, including patients, regulators and industry. Finally he emphasizes the need that future funding calls for similar academic-industry consortia focusing on addressing 'gaps in academic research and the needs of industrial product development' and sharing the data so all stakeholders can benefit. The full article can be accessed here R. Holm, Bridging the gaps between academic research and industrial product developments ..., Adv.Drug Deliv. Rev., https://doi.org/10.1016/j.addr.2019.01.009
PEARRL publishes an open access special issue of J. Pharm. Pharmacol. on approaches for accelerating R&D for faster #accesstomedicines
In February 2019, the PEARRL network published a special 'PEARRL themed' issue in Journal of Pharmacy & Pharmacology on innovative drug development strategies tailored to facilitate earlier access to new oral medicines. This dedicated issue of the J. Pharm. Pharmacol. hosts a collection of eleven review articles that showcase the research topics that are the focus of the PEARRL consortium. The objective of these review articles is to provide an up‐to‐date review on the current status of the target areas of research and to highlight approaches which can be used to streamline oral drug product. Each of the 15 ESRs in PEARRL contributed, both individually and collectively, to publishing these reviews. In addition, our industrial partners made significant contributions to these joint publications, which serves to highlight the industrial relevance of these reviews. Overall, 34 authors from 11 institutions within the PEARRL network were involved in preparing this special issue. We do hope you enjoy the read!
The full list of articles can be accessed from her:
THE PEARRL REVIEWS ‐ innovative drug development strategies tailored to facilitate earlier access to new oral medicines: Journal of Pharmacy and Pharmacology : Vol 71 , No 4 https://onlinelibrary.wiley.com/toc/20427158/2019/71/4
The 3rd PEARRL Annual Meeting will be held at National and Kapodistrian University of Athens, Department of Pharmacy, Greece from Monday, 10 June 2018 to Friday 14 June 2019. The local organisers, Prof. Christos Reppas, Dr. Maria Vertzoni and their team, have pulled out all the stops in planning for what is shaping up to be an exciting scientific meeting. Building on the success of the 2017 and 2018 Annual Meetings and associated Symposia, the theme of the 2019 PEARRL symposium has been selected to be Model Informed Drug Development. As the symposium is open, we are expecting significant interest from external participants*.
The agenda has been published on the website, which includes up to 25 presentations dedicated to exploring the use of modelling tools for streamlining drug development. The theme on the 12th June is on "Lead optimisation through to pre-clinical development" and on the13th June the focus moves to "Model informed Clinical development through to emerging trends in pharmaceutical product lifecycle management".
An exciting list of external speakers has already been confirmed which includes:
· Jochem Alsenz, F. Hoffmann- La Roche Ltd. Basel, Switzerland
· Bertil Abrahamsson, AstraZeneca R&D, Sweden
· James Butler, GlaxoSmithKline, UK
· Sandy Van Hemelryck, Janssen Pharmaceutica, Belgium
· Masoud Jamei, Certara, United Kingdom
· Neil John Parrott, F. Hoffmann- La Roche Ltd., Basel, Switzerland
· Christian Wagner, Merck Group, Germany
In addition, a key highlight of the 2019 meeting is that all ESRs will present at this open symposium on topics related to research in the PEARRL network. For More information on the symposium, with speaker bibliographies, please visit https://www.pearrl.eu/rss2019.html.
*So if you are interested in attending on 12th and/or 13th you should register your interest via the website. Please note spaces are limited so early registration is essential!
As PEARRL is a European Training Network (ETN) which delivers a unique research and training programme for 15 ESRs, three additional days of research and training activities are scheduled on 10th, 11th and 14th for PEARRL members. Further details on the agenda for these ‘PEARRLs of Wisdom days’ can be viewed here https://www.pearrl.eu/am2019.html
To receive live updates and photos during the event follow us on twitter @pearrl_eu
Female STEM students from St Brendan's sixth form college had the opportunity to hear about the PEARRL project.
The talk provided fantastic insight into the world of pharmaceuticals and many members of the female audience left feeling empowered to pursue a career within the field and research opportunities with the European Training Network.
Read the full article: www.stbrn.ac.uk/info/news-and-blogs/news/female-stem-students-inspired/
PEARRL researcher Professor Jennifer Dressman features in the latest “Highly Cited Researchers” worldwide!
PEARRL researcher Professor Jennifer Dressman was recently recognised for her exceptional research publications in pharmaceutical science and technology. Professor Dressman features in the latest “Highly Cited Researchers” list. The Highly Cited List is produced by Clarivate Analytics for the Web of Science, and recognises the most influential researchers who are leading the way in solving the world’s biggest challenges in across diverse scientific fields, including engineering, neuroscience, mathematics, and social sciences, among others. Determined on a global basis, these are researchers who are most highly cited in research publications by their peers, positioning them in the very highest strata of influence and impact. Professor Dressman is now being recognised among this elite group of researchers, which includes 17 Nobel laureates.
Professor Dressman‘s research publications are classified in the top 1% of the most cited papers in ‘Pharmacology and Toxicology’ research globally. She has published >300 research publications, which have been cited in excess of 10,000 times and has an overall h-index of 63. Her research has provided significant advances in the field of pharmaceutical technology and biopharmaceutics, specifically in shedding new insights into strategies to improve drug solubility for enhancing oral delivery, her pioneering the use of Biorelevant dissolution testing and in advancing the use of physiologically based pharmacokinetic (PBPK) modelling to achieve quantitative predictions of oral absorption.
More information about Professor Dressman’s research can be found at her university website.
On 8th January 2019 Patrick O'Dwyer contributed to the UCC School of Pharmcy's open day with a PEARRLs for Girls session. Patrick gave a presentation to a class of 53 secondary school students on insights into possible career paths for pharmacy students, future research opportunities and the project PEARRL itself. The young adults showed a keen interest in the subject at hand and the event was an overall success.
PEARRLs for Girls - PEARRL researchers promote Careers in science during schools visits to University of Athens
ESRs from UoA met secondary students from three high schools on November 6th. Dr Maria Vertzoni presented the reserved objectives of the PEARRL EU network and answered questions from the interested students. Christina (ESR 7), Marina (ESR 11), and Patrick (ESR 10), who is currently completing his academic secondment at the UoA, accompanied the students during the undergraduate labs’ visits and had the opportunity to talk about careers in science under Marie Sklodowska-Curie Actions, potential science perspectives and possibilities of starting an academic pathway.
The European Researchers’ Night is a Europe-wide event involving over 300 cities in around 30 countries. The event is supported by the European Commission and promotes science, fun learning and research careers. The European Researchers' Nights take place on the last Friday of September and have been organised every September since 2005.
PEARRL was involved in the European Researchers’ Night 2018 in Cork and Bristol that took place on Friday 28 September.
Cork discovers - European Researchers’ Night in Cork
PEARRL was involved in the Career Café event. A location where the public could meet researchers in a more informal setting and learn about their interests, their day-to-day life and their research projects.
FUTURES - European Researchers’ Night in Bristol and Bath
PEARRL was involved in the Photography Chinese Whispers, a means for researchers from the South West of England and Catalonia to tell the public about their research.
The principle: One single picture was sent to three different researchers that in turn produced a picture that they sent to another researcher, producing three chains of reaction to the picture. The idea is that when receiving the picture the researchers had to create a photographic response to it keeping some elements from the picture they had just received and at the same time introducing elements of their own research and of the way they see their day to day life as a researcher.
During the European Researchers’ Night the photos were exhibited at different venues in Bristol and Catalonia, but you can also check them out online: