The researchers have created poly(amino acid)-polyester graft copolymers by combining N-carboxyanhydride (NCA) ring-opening polymersiations (ROP) and O-carboxyanhydride (OCA) ROP. These were “capable of self-assembly in aqueous media to form discrete nanoparticles” (Price et al. 2017).
Daniel and his colleagues show that the polymers in question are very promising candidates for the controlled release of chemotherpeutics directly at tumour sites, thus avoiding the unpleasant side-effects associated with off-target pharmacology of chemotherapy.
The full article is available on Royal Society of Chemistry.
Coming up: Daniel will present a poster on in silico selection of precipitation inhibitors for supersaturable formulations at the 2017 AAPS Annual Meeting and Exposition in San Diego, California.
Daniel Price, one of PEARRL’s Early Stage Researchers has published his first scientific paper as lead author in Chemical Communications this month entitled “Poly(amino acid)-polyester graft copolymer nanoparticles for the acid-mediated release of doxorubicin”. This research was carried out at the School of Chemistry, University of Leeds, before Daniel joined Merck and the PEARRL project for his PhD studies.